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We all have our own day-to-day routines, and that means the same injection schedule won't work for everyone. Rapid-acting insulin analogues are taken right before or right after a meal. Short-acting insulin is taken 30 minutes before you eat. Intermediate-acting insulin is taken once or twice a day, at breakfast or bedtime-or both. Pre-mixed insulin is a combination of short-acting and intermediate-acting insulin. If you take long-acting insulin, you might only need one injection daily.